Subcellular Organization: Change of Phase in Partitioning the Cellular Milieu

نویسندگان

  • Joe Swift
  • Dennis E. Discher
چکیده

Spatial organization and segregation are essential for the function of a complex and crowded cellular machine. New work demonstrates liquid-gel phase separation, both in vitro and in vivo, driven by the valency of constituent proteins.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Cadmium on Cellular and Subcellular Structures of Cerebellar Purkinje Cells in Four-Day Postnatal Developing Rat

Purpose: This experiment was conducted to evaluate the effects of Cd on cellular and subcellular aspects of cerebellar Purkinje cells in developing rats. Materials and methods: forty adult female Wistar rats served as subjects in this experiment. The animals were assigned randomly to four groups: control I, control II, experiment I and experiment II. The experiment group I and II were injected...

متن کامل

Response Surface Methodology for the Evaluation of Lysozyme Partitioning in Poly (Vinyl Pyrrolidone) and Potassium Phosphate Aqueous Two-Phase System

The partitioning of lysozyme and extraction yield in an aqueous two-phase system containing Poly Vinyl Pyrrolidone (PVP) K25 and potassium phosphate were investigated as a function of weight percent of salt and PVP in the feed, temperature, and pH. To investigate partitioning behavior, the central composite design was considered using a quadratic model. According to the results of the model...

متن کامل

Dynamics of alaninaminotransferase activity in subcellular fractions of different areas of brain cortex and hypothalamus in postnatal ontogenesis under protein-free feeding regime and after its withdrawal

Total and specific activities of alaninaminotransferase (Al-AT) were determined in general tissues, mitochondrial and cytosol fractions of visual, orbital, motor, limbic areas of brain cortex and hypothalamus of three-month old and one-year old rats under 10-20 days and 30 days protein deprivation and under recovery of normal food regime during the same terms. It was found out that Al-AT activi...

متن کامل

Impaired Memory and Evidence of Histopathology in CA1 Pyramidal Neurons through Injection of Aβ1-42 Peptides into the Frontal Cortices of Rat

Introduction: Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which has much benefited from animal models to find the basics of its pathophysiology. In our previous work (Haghani, Shabani, Javan, Motamedi, & Janahmadi, 2012), a non-transgenic rat model of AD was used in electrophysiological studies. However, we did not investigate the histological aspects in the ...

متن کامل

Dynamics of alaninaminotransferase activity in subcellular fractions of different areas of brain cortex and hypothalamus in postnatal ontogenesis under protein-free feeding regime and after its withdrawal

Total and specific activities of alaninaminotransferase (Al-AT) were determined in general tissues, mitochondrial and cytosol fractions of visual, orbital, motor, limbic areas of brain cortex and hypothalamus of three-month old and one-year old rats under 10-20 days and 30 days protein deprivation and under recovery of normal food regime during the same terms. It was found out that Al-AT activi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Current Biology

دوره 22  شماره 

صفحات  -

تاریخ انتشار 2012